Endocrine Abstracts

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

PRL hypersecretion is the most common endocrine abnormality due to hypothalamic–pituitary disorders. PRL is the hormone most commonly secreted in excess by pituitary adenomas. Patients usually present with oligo-amenorrhea, galactorrhea, loss of libido, impotence and infertility. If the tumor extends outside of the sella, visual deficit or other mass effects may be seen.A retrospective study was performed during the period 1999–2008. The diagno...

Background: Acromegaly is a relatively uncommon disorder (40–68 cases per million population) caused by oversecretion of growth hormone by a tumor of the pituitary gland. Excessive growth hormone (GH) and insulin-like growth factor (IGF) I concentrations cause gradual changes in facial and acral appearances as well as in many internal tissues.Medhods: Medical records of patients with acromegaly seen between 2000 and 2008 at our hospital were reviewe...

Background: Among the disorders causing hyperthyroidism thyrotropin-secreting pituitary adenomas (TSH-omas) are extremely rare and account for <2% of all pituitary adenomas. Failure to recognize a TSH-oma may lead to improper therapy attempts and dramatic consequences. We have reported a patient that wrongly had diagnosed and treated as primary hyperthyroidism for fifteen years.Case: A 50 years old woman who was on the treatment of propilhyourasil (1...

Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All...

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...

Increased heel pad thickness can be used as a marker of soft tissue enlargement in acromegalic patients. We aimed to investigate if concomittant hyperinsulinemia/and or diabetes secondary to insulin resistance in acromegaly contribute to the enlargement of heel pad. We compared heel pad thickness in 16 diabetic and 16 nondiabetic active acromegalic patients using X-ray images. All of the diabetics were well controlled with diet and/ or oral antidiabetic drugs. GH and IGF-1 wer...

Introduction: Hemochromatosis is an iron storage disease characterized by iron deposition in parenchymal cells due to increased intestinal iron absorption. Iron overload leads to tissue damage and dysfunction particularly in the liver, pancreas, heart, joints, and pituitary gland. Panhypopituitarism is a clinical condition in which the anterior pituitary gland hormones are deficient. Herein we report a very rare case of panhypopituitarism due to hemochromatosis.<p class="a...

To asses the presence of antibodies to BIP/GRP78, which is a chaperon of endoplasmic reticulum and has immune modulating and antiapoptotic effects in Hashimoto’s thyroiditis.The study included 62 patients with autoimmune thyroiditis. Of these, 20 had euthyroid, 27 had subclinical hypothyroid, and 15 had hypothyroid Hashimato’s thyroiditis. A control group including 37 healthy patients also participated in the study.There ...